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U.S. stock futures opened lower Wednesday amid lingering anxiety about a possible economic slowdown and continued murkiness around trade relations with China.

On Wednesday evening, futures initially indicated that the Dow Jones Industrial Average would open 400 points lower. Dow futures fell as much as 486 points at their lows. Markets have since recovered and, as of 6:36 p.m., ET, indicated that the Dow would open more than 200 points lower on Thursday.

The New York Stock Exchange, Nasdaq and U.S. Treasury market were closed Wednesday as the nation remembered former president George H.W. Bush.

On Tuesday, the Dow Jones Industrial Average shed nearly 800 points in its largest decline since Oct. 10.

On Monday, the yield on the three-year Treasury note surpassed its five-year counterpart. That bond-market phenomenon, known as a yield-curve inversion, is seen as a recession signal. But typically the recession doesn’t come until years after and many traders won’t see the inversion as official until the two-year yield rises above the 10-year yield.

Investors remain uncertain about the prospects of a permanent trade deal with China. Over the weekend, President Donald Trump met with Chinese President Xi Jinping to discuss ongoing trade quarrels between their two countries. While the White House has said it has worked out a cease-fire with Beijing, discrepancies in messaging haven’t assuaged market fears of uncertainty.

—CNBC’s Fred Imbert contributed to this report.

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